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Normally vitamin D is produced in the skin by sunlight, taken through supplements and found in oily fish, such as sardines, herring, salmon and mackerel, after which it is converted by several steps in the body into the active form, which provides the health benefits

This disruption and subsequent infiltration of inflammatory mediators are associated with cognitive impairment in CKD patients, providing further evidence of a gut-brain connection (Sun et al., 2021)

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Finally, we also compute the variance explained in the dependent clinical set by the biomarker set