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instead, it undergoes proteolytic degradation similar to endogenous proteins, which contributes to its low drug-drug interaction potential via hepatic pathways

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Little SA, Speight J, Leelarathna L et al (2018) Sustained reduction in severe hypoglycemia in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: two-year follow-up in the HypoCOMPaSS randomized clinical trial

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(2015) 7:283ra52283ra52

Binding of GIP to its receptor also stimulates glucose-dependent insulin secretion and produces a greater proportion of the incretin effect than GLP-1 (about 45% for GIP and 29% for GLP-1) [133]