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Additionally, a multi-country study found substantial demand for GLP-1 medications among people without medical indications, highlighting the evolving landscape of body image and obesity treatment (Jensen et al., 2025)

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The longer duration (68 weeks vs 48 weeks in Phase 2) allowed assessment of sustained efficacy

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cocaine, for example, is used as a local anesthetic (Chapter 2), and amphetamines and methylphenidate are used in low doses to treat attention deficit hyperactivity disorder and in higher doses to treat narcolepsy (Chapter 12)

The compartments considered included blood sinusoids, hepatocellular cytoplasm, and bile canaliculi