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This is a legal and established route, but it carries important distinctions from FDA-approved medications: compounded formulations are not evaluated for purity, potency, or sterility by the FDA on a routine basis

They are therefore known as the chain-breaking antioxidants because they can directly interact with the radicals to transform them into nonradicals, consequently preventing them from further peroxidation

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For severe cases, biologics and traditional systemic agents like methotrexate, retinoids, and cyclosporine are more common choices (Nakamura & Koo 2020

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[11] Methionine salvage [edit source] Homocysteine can be recycled into methionine