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However, under conditions of stress and inhibition of the electron transport chain, the enzyme works in the opposite direction by transferring electrons from NADPH to NAD + , which impairs mitochondrial antioxidant defenses and feeds more reducing equivalents into the impaired electron transport chain leading to increased electron leakage and superoxide formation [133]

In in vivo experiments, using a leukemia mouse model, it was confirmed that HDACi pretreatment or oral administration of Citarabine (10 mg/kg) after infusion significantly reduced tumor burden and prolonged survival

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