Revista Brasileira de Ginecologia e Obstetricia
Marine vs
Retatrutides main obesity trial, TRIUMPH-1, is ongoing in adults living with obesity but without knee osteoarthritis
A realistic timeline, based on where the Phase 3 programme is now, looks like this: FDA submission in the U.S.: late 2026 or 2027 FDA approval: 2027 or 2028 UK MHRA review: typically 12 to 24 months after FDA approval NHS access through a NICE appraisal: a separate process, usually 12 to 24 months after MHRA approval The earliest UK private access through online pharmacies, mirroring how Mounjaro and Wegovy first launched here, is likely 2027 or 2028
The evidence bases are different
Safety, Side Effects, and Medical Supervision Considerations Both semaglutide and tirzepatide carry similar safety profiles, with nausea, vomiting, and constipation as common early side effects that typically resolve within 2-4 weeks