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Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

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doi: 10.1136/bmj-2022-070856 2 DingQHuWWangRYangQZhuMLiMet al

For species possessing a higher number of genes, the increase is not due to tandem duplication as the genes are neither found at adjacent positions nor on the same chromosome in most cases