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Randomized clinical trial (2025): A double-blind RCT found once-weekly semaglutide reduced alcohol craving and heavy drinking versus placebo in adults with AUD, supporting larger confirmatory trials

But other research points in the opposite direction

Conclusion The addition of glucagon receptor activation to GLP-1based pharmacotherapy appears paradoxical only when glucagon is considered in isolation

Author contributions AS conducted bioinformatic analyses related to biomarker, clustering, and association analyses

Many athletes time their injection 4-5 days before a key race to minimize GI impact while maintaining therapeutic benefit

This is especially relevant for GLP-1 users who report feeling like the stool is right there but will not come out, or who experience excessive straining despite having soft stool