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Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management

NICE guidance on osteoarthritis (NG226: Osteoarthritis in over 16s: diagnosis and management) and obesity management (CG189: Obesity: identification, assessment and management) both acknowledge the musculoskeletal benefits of sustained weight loss, including improvements in knee and hip pain

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[DOI] [PMC free article] [PubMed] [Google Scholar] [26].Liu R, Choi J

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As shown in Figure 2, body mass declined during fasting in the LC group to a significantly larger degree than that observed in the CT group (LC vs