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Obesity-associated inflammation accelerates NAD consumption through activation of NAD-utilizing enzymes such as poly(ADP-ribose) polymerase 1 (PARP-1) and cluster of differentiation 38 (CD38) [85]

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Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

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