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Constipation is reported in approximately 10-20% of patients taking GLP-1 weight loss drugs

Relative muscle size (normalized to body weight) was not negatively affected

3.3 Tirzepatide effects: cardiovascular, renal, hepatic, and other metabolic effects of tirzepatide Due to concerns that type 2 diabetes medications increased cardiovascular risk, the FDA issued guidance for pharmaceutical companies to perform cardiovascular outcomes trials for new diabetes medications

If they are severe, ongoing, or getting worse, contact your healthcare provider

W., Rosenstock, J., Canani, L

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists