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Relevant reviews have reported serious adverse events associated with GLP-1RAs, among which gastrointestinal diseases (commonly nausea, diarrhea, vomiting and constipation) are the most frequently reported

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In some cases, temporary dose reduction or switching to a different GLP-1 compoundsuch as oral semaglutide or the Microdose GLP-1 Protocolmay reduce digestive side effects entirely

Authors contributions ROM, RC and RCLAC contributed equally to the literature review and elaboration of this manuscript

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