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By targeting both receptors, these medications may provide enhanced metabolic effects for some patients, as determined by the prescribing clinician

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10.1038/nrdp.2017.38 48 KoonsG

van Kapel, L.J.M

Patients start at 2.5 mg weekly and increase in 2.5 mg increments every four weeks, eventually reaching maintenance doses of 10 mg or 15 mg depending on tolerance and response

The causes underlying these effects remain unclear, though it is interesting to note that several enzymes involved in synthesis or metabolism of some of these amino acids are among those that have been identified as potential TRX targets through redox protemics approaches (Montrichard et al., 2009)