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Note on amyloid aggregation: Cagrilintide has proline substitutions at positions 25, 28, 29 , which dramatically reduce the amyloidogenic potential

One of the cleaner ones, a 24-week randomized study of 279 mild-to-moderate Alzheimers patients, tested three doses against placebo and found a result no marketer would have designed: the lowest dose, 10 mL a day, beat placebo on both a cognitive scale and a global clinical rating, while the higher 30 and 60 mL doses improved the global rating but not cognition (Alvarez et al., Eur J Neurol 2006, randomized controlled trial)

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Biological Psychiatry, 74 (10), 720-726

APP1180929) and a Discovery Project from the Australian Research Council (DP230100747)