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The authors note that the diagnosis was based on morphology and low MIB-1 index

Patients on extended protocols should supplement zinc (1530mg daily) and selenium (100200mcg daily)

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GSIS, Glucose-stimulated insulin secretion

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This decision was informed by the documented adverse gastrointestinal effects associated with higher doses of this GLP-1 agonist, as indicated by pica behavior (Kanoski et al., 2012) and the known effect of this dosing in heroin and alcohol models (Marty et al., 2020