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Priprem A, Johns JR, Limsitthichaikoon S, Limphirat W, Mahakunakorn P, Johns NP

Typical weightloss results on semaglutide, tirzepatide, and others Although typical weight-loss results on semaglutide, tirzepatide, and other GLP-1 medications can vary, both semaglutide and tirzepatide have been seen to help provide meaningful average weight loss

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Regarding cardiovascular and renal effects, the two drug classes appear to work additively: SGLT2is primarily exert their cardiovascular benefits through hemodynamic effects, while GLP-1RAs mainly work through anti-atherogenic and anti-inflammatory actions 26