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Induction of apoptosis in AML by HA14-1, a small molecule Bcl-2 antagonist is independent of caspases-8 and 9

Endogenous creatine synthesis also consumes methyl groups, so high creatine demand may place additional pressure on SAM-dependent methylation

PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

While glutathione synthesis is controlled by multiple factors, GCL is the main determinant, because the rate-limiting step is the cellular level of the amino acid cysteine

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One lung was homogenized in BSAN buffer as described in the PROCEDURE