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The absence of substantial modern follow-up research may reflect limited reproducibility, insufficient clinical benefit, pharmaceutical development challenges, or reduced scientific interest relative to newer sleep therapeutics [1617]

Should metformin dose be increased first in a patient with type 2 diabetes mellitus, HbA1c 5.8%, taking metformin 500 mg daily, phentermine, and NP thyroid 60 mg daily, with poor diet and exercise compliance, before considering GLP-1 receptor agonists?

doi: 10.1245/s10434-017-5982-4 19 HelyerLKVarnicMLeLWLeongWMcCreadyD

Others require more carbohydrates to fuel intensive training sessions

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