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In addition, it also converts melanin to pheomelanin, a lighter, reddish pigment, as opposed to eumelanin, the darker pigment

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Of note, a US national survey (NHANES III) reported that over 99% of the US participants had serum selenium concentrations consistent with selenium requirements being met (65), suggesting selenium supplementation is not needed for most Americans

2011 Jan;96(1):150-8

Proteolytic activation of jr PPO1-wt In vivo activation of PPOs is achieved by cleavage in-between the C- and N-terminal domain 45