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This process involves a small ubiquitin-like modifier (SUMO), which is a ubiquitin-like protein that is conjugated to lysines on p53 through a mechanism similar to ubiquitination

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Furthermore, another phase II trial, designed to assess the effect of CDDO-methyl ester on renal function in patients with DKD, revealed that CDDO-methyl ester significantly enhanced eGFR in patients with DKD