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After the shortage ended, companies were supposed to wind down the manufacturing and prescribing of compound semaglutide

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The root causes go unaddressed Insulin resistance, sex hormone decline (testosterone, estrogen, progesterone), thyroid dysfunction, mitochondrial inefficiency, and chronic inflammation all drive weight gain through mechanisms that appetite suppression does not touch

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Wegovy (approved for weight loss) experienced months-long shortages that ended in December 2022, at which point first-time on-label prescribing increased sharply