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Based on articles retrieved from PubMed, a 2020 meta-analysis in Complementary Therapies in Medicine pooling 12 trials and 849 subjects found no statistically significant reduction in overall body weight or BMI, but did find a meaningful reduction in waist-hip ratio, which reflects visceral fat specifically
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Magoulas PL, El-Hattab AW
For research protocol design purposes, this suggests that 48 weeks may be an insufficient observation window to capture the full weight loss potential of retatrutide at the 12mg dose
(PubMed) Soares MJ, Satyanarayana K, Bamji MS, Jacob CM, Ramana YV, Rao SS
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