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The latter means that the binding of the dinitrosyldiglutathionyliron complex to one subunit of GST makes the binding of it to another subunit less favorable (negative cooperativity), demonstrating that the basal enzymatic activity of GSTs has a protective mechanism [174]

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129 Preclinical studies in various PD animal models indicate that GLP-1RAs such as liraglutide, semaglutide, and lixisenatide promote dopamine synthesis and elevate striatal dopamine levels, thereby conferring neuroprotection to dopaminergic neurons

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With a chemical structure similar to other essential compounds in human body, administration of carnitine was supposed to be not harmful

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10.1021/acs.biomac.5c00342 27 HansenL

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