Figure from van der Aart-van der Beek AB, Nat Rev Nephrol, 2020 The Study Methods This was an international, event-driven, double-blind, parallel-group, randomized, placebo-controlled trial conducted at 387 sites in 28 countries comparing semaglutide to placebo in patients with T2DM and CKD, both being treated with baseline standard of care
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Patients with a BMI of 27 or higher may also qualify if they have weight-related comorbidities such as type 2 diabetes, high blood pressure, high cholesterol, or sleep apnea
For more severe gallbladder issues, such as acute cholecystitis or symptomatic gallstones requiring surgical intervention, pausing semaglutide might be necessary
For many patients, measurable weight loss, increased comfort and confidence in clothing and lifestyle choices, and better mobility after having gained energy typically happen after their first three months on semaglutide
