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The Ussing chamber technique is often utilised in animal studies where intestinal tissues may be obtained following sacrifice of the animals [41, 42] and in human studies of intestinal diseases where endoscopic biopsy samples may be obtained [43]

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Although we did not test for the development of antidrug antibodies to secukinumab, there is evidence that the incidence of such development is exceedingly low and not correlated with clinical efficacy

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