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The regulation of cytokines during OA inflammation by targeting HIF has been demonstrated by many studies, but there is still a lack of evidence for the targeted regulation of glucose metabolic pathways (especially aerobic glycolysis) by HIF in OA chondrocytes (96, 97)
For doses above 100 units (1mL), you may need a larger syringe or split the dose into two injections
Treatment-emergent adverse events (TEAEs) were defined as events that had an onset date on or after the first day of exposure to study drug and no later than the follow-up visit, or those that were present before randomization and increased in severity during the treatment period and no later than the follow-up visit (35 days after the last dose of semaglutide)
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