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A Knife Through Hot Butter: The Rise of GLP-1s through the Eyes of Intuitive Surgical Competition is perhaps the single most important dynamic to understand when evaluating companies

Recent study shows that overactivation of MYC detected in ALS astrocytes induce alterations in EV release and these alterations trigger astrocyte-to-neuron miscommunication, resulting in reduced support of neighboring neurons (Fioretti et al., 2025)

FLOW - kidney-outcomes benefit at 1.0 mg

Fewer surface receptors = the drug has less to bind to = weaker effect over time

These receptor pharmacology studies have contributed to the fundamental question of whether biased agonism is a pharmacologically exploitable variable for next-generation GLP-1R agonist optimisation

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