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Is it a direct brain effect

Expect waves of mild nausea, bloating, or slower stomach emptying during dose increases, which then settle if you keep the dose the same, as your body needs time to adjust

These carbs are stripped of most nutrition and can lead to spikes in your blood sugar

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These indirect mechanisms allow for central nervous system modulation without requiring substantial penetration of the blood-brain barrier, though direct human data on CNS distribution of long-acting incretin agonists remain limited

PMC 2428351