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[26] GLP-1 exerts its metabolic effects through activation of GLP-1 receptors (GLP-1R) distributed throughout multiple organ systems, including the pancreas, brain, gastrointestinal tract, and cardiovascular system

Conservative measures like exercise, diet and behavioral modifications are some of the initial ways to lose weight

But it won't have five years of real-world use

Adequate calcium (700mg daily), vitamin D (10 micrograms daily), protein intake, and weight-bearing exercise help protect bone health during treatment

doi: 10.1006/cyto.1999.0533 62 BoosCJWoodsDRVariasABiscochoSHeseltinePMellorAJ

Always follow the manufacturer's guidelines and consult a healthcare provider for personalized recommendations