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For the broader obesity pharmacology field, it opens a template for central drugs that operate where peripheral gut-hormone therapies cannot reach
Firstly, tirzepatide promotes weight loss , which can lead to reductions in blood pressurea generally beneficial effect, but one that may unmask or exacerbate postural hypotension in predisposed individuals
Phytomed 1, 1726
A single daily injection will not work
Retatrutide may be worth pursuing through clinical trial enrollment for patients with severe obesity (BMI above 40) who have not achieved adequate weight loss on existing therapies and who meet trial eligibility
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