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Pepsin cleaves the His-D-2-Nal bond, separating the N-terminal dipeptide (Aib-His) from the C-terminal tripeptide (D-2-Nal-D-Phe-Lys-NH2)

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The observed differential mRNA and protein expression levels of GPX4 and TfR1 in vitro may bear clinical relevance when considering factors such as tumor heterogeneity and the wide-ranging therapeutic response of thyroid tumors harboring diverse mutational signatures

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A clinician can help you sort through which of these fits your case