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Although the reactions catalysed by Gdh2 and Gdh3 are reversible, the Gdh2-catalysed reaction favours the deamination of glutamateits catabolism to -ketoglutarate and ammonium 12

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ROB, risk of bias

In India, the initial composition patent expired in September 2024, and subsequent formulation and delivery system patents are scheduled to lapse in March 2026

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There is no pharmacological requirement for this separation, but individual comfort matters for long-term adherence