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Chen and colleagues developed pH-responsive polymeric micelles encapsulating DOX for dual-function aggregation-induced emission (AIE) imaging and chemotherapy 139

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Martello E, Perondi F, Bisanzio D, Lippi I, Meineri G, Gabriele V

The peptide has a uniquely high affinity for copper ions, forming a stable chelate with copper(II) that is more exchangeable than the copper bound to albumin, allowing efficient copper delivery to tissues

As expected, we reported a lower percentage of viable CCs during the summer season as well as a higher percentage of dead cells than during the other seasons

Animal studies and a very small uncontrolled human pilot study exist