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Your provider will adjust every four weeks until you reach your optimal dose, semaglutide around 2.4 mg, tirzepatide around 5, 10, or 15 mg

External resources NEJM Phase 2 Trial: Triple Hormone Receptor Agonist Retatrutide for Obesity PMC Review: Retatrutide - A Game Changer in Obesity Pharmacotherapy ClinicalTrials.gov: Retatrutide TRIUMPH Clinical Trial Registry Nature Medicine: Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease For researchers serious about optimizing their retatrutide protocols, SeekPeptides offers the most comprehensive resource available, with evidence-based guides, personalized protocol builders, dosing calculators, and a community of thousands who have navigated these exact questions

Who Might Need the Triple Agonist Power of Retatrutide

Rachele Pojedic, Chief Science Officer at Restore

It activates all three receptors: GLP-1, GIP, and the glucagon receptor