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MC3R & MC4R: Heavily concentrated in the brain, particularly the hypothalamus

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doi: 10.1007/s00418-002-0400-8

These genes control the entire steroid-to-hormone conversion process by being linked to important enzymes that convert steroids into steroid hormones 88 , which corroborates our findings

While this creates a daytime pulse and may boost morning energy and alertness, it doesn't leverage the robust nocturnal pulse and sleep-associated benefits of bedtime dosing