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Andrographolide, a ladanditerpene extracted from Andrographis paniculata, is a MAPK/Nrf2 pathway activator (Yang et al., 2017)

Documented across 500+ peer-reviewed studies on tissue repair

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PMID 8717520

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This allows it to reach tissues that wouldnt normally get much ALA which may explain why higher supplemental doses (like 600mg) can affect nerve health, blood sugar, and oxidative stress in ways your bodys natural supply cant.12 Once you take ALA as a supplement, several factors affect how well your body absorbs and uses it