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In this regard, MAD fundamentally contrasts with the amyloid cascade hypothesis in the notion that A is the central driver of AD, but incorporates it in a more holistic perspective with microbes instead as the central driver

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Beyond cognitive enhancement, VR could serve as a diagnostic and prognostic tool, allowing for the assessment of subtle impairments in spatial navigation, attention, and executive function, which are often the earliest markers of neurodegeneration (Brugada-Ramentol et al., 2022)

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