While complete avoidance is unrealistic, exposure reduction and effective elimination are both achievableand clinically meaningful
10.1073/pnas.0407162101 37 EslerM
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The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism
Instead, it affects gene activity tied to GABA and has an influence on inhibitory signals
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