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Numerous S -nitrosylated proteins such as Bcl-2, p53, HIF-1, PTEN, and Src are involved in cell survival, angiogenesis, tumorigenesis, and response to cancer treatment (6368)

*Correspondence: Min Liu, [email protected]

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67 For instance, genotypes of GSTs have been linked to higher risks of lung, 68 bladder, 69 and colorectal cancers

Indeed, an increased risk of wheezing is associated with the presence of GSTM1 and GSTT1 genotypes, respectively, in mothers exposed to acetaminophen [101]

Finally, dysfunction of the p53 pathwayvia MDM2 overexpression or TP53 mutationimpairs transcriptional induction of pro-apoptotic targets such as Bax and PUMA, substantially reducing tumor cell sensitivity to DNA-damaging agents (4754)