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Oxoproline catalytically activates the uptake of amino acids through the placental barrier, and the transfer of amino acids through the bloodbrain barrier is activated by oxoproline (2, 75)

Consistent with enriched glycerophospholipid and amino acid metabolism, levels of the phospholipids phosphoethanolamine, glycerol 3-phosphate, CDP-ethanolamine as well as the amino acids glutamine, serine, and cis-4-Hydroxy-D-proline were increased in rapamycin-treated CAR T cell products (Fig

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