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Nevertheless, if its senolytic action has been demonstrated in several diseases such as osteoarthritis 15,16 as well as in neurodegenerative diseases 17 , the effect of ABT-263 is restricted to senescent cells from specific cell types 18 , leading to the necessity to identify new potential senolytics to target senescent cells in age-related diseases

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Nat Rev Drug Discov (2007) 6:3412 10.1038/nrd2314 [DOI] [PubMed] [Google Scholar] 41.Hardy J, Selkoe DJ

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This demand is reinforced by the shift toward minimally invasive cosmetic procedures, where GHK-Cu-based products serve as non-invasive alternatives, further accelerating adoption

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