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Analysis of patients biological fluids by Mass Spectrometry (MS) or NMR spectroscopy helps identify pre-drug metabolomics signatures that can predict the post-drug exposure effects and provides molecular basis for variability in drug response

Moreover, when PKC is overexpressed, it can exacerbate oxidative stress by stimulating NADPH-oxidases and lipoxygenases, which are enzymes known to generate ROS, as evidenced in human platelet suspensions [67]

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Monolayers were lysed with 0.2% TritonX (0.5 mL) in Milli-Q H 2 O by shaking for 20 min at room temperature