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Among Medicare patients, 18% started with a GLP-1 while 24% used an SGLT2, reflecting the higher prevalence of cardiovascular conditions in seniors and the dual benefits SGLT2s provide in heart health
They are the weeks or months lost to avoidable protocol errors
In the STEP-UP trial, the 7.2 mg dose produced 20.7% weight loss at 72 weeks, much closer to Mounjaro 15 mg than the 2.4 mg dose tested in SURMOUNT-5
What side effects of GLP-1s should be considered
It also promotes hepatic fat oxidation, meaning the liver breaks down stored fat more aggressively
Retatrutide is studied in research settings as a triple glucagon / GIP / GLP-1 receptor agonist, with interest in multi-incretin signaling, energy-expenditure models, food-intake models, glycemic endpoints, and body-composition research
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