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(PubMed)

For the first week or two, tirzepatide is still providing most of the GLP-1 receptor activation

Investigating the same primary endpoint, TRANSCEND-T2D-2 (NCT06260722) will compare retatrutide to semaglutide in people with inadequately controlled T2D (treated with oral glucose-lowering treatments) over 26 months

The analysis also drew on linked electronic health record and prescription-dispensing data, and included obesity treatment at both specialist and generalist care settings

Another concern is the commonly encountered gastrointestinal adverse events during treatment with GLP-1RAs, albethey of mild-to-moderate severity in most cases, which may limit the tolerability

Eye surgery can be performed under eye block, topical anaesthesia or general anaesthesia