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GLP-1 Agonist plus IL-17 Inhibition in Obese Psoriatic Arthritis Save Lilly announced the topline results from its phase 3b "TOGETHER PsA" trial, showing that the combination use of ixekizumab (Taltz) and tirzepatide (Zepbound) was superior to IXE alone, yielding both significant weight loss and ACR50 disease control in adults with active psoriatic arthritis (PsA)

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(2) enhancement of mitochondrial function and attenuation of oxidative stress by reducing reactive oxygen species, thereby offering protection against the cellular damage characteristic of RA

Polycystic ovary syndrome creates insulin resistance that partially counteracts GLP-1 effects

Six studies used a composite outcome, and the component outcomes differed

Quality varies significantly, and patients need to evaluate potential sources carefully