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These beneficial effects may be due to the formation of detour circuitswhich encompass spared tissue surrounding the lesionand could reconnect locomotor circuits [69], thus enabling afferent inputs to be processed and conveyed to the cortex [73] and improving spinal reflexes, even below the injury [74]

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Therapeutic approaches, contingent upon the specific clinical manifestations and overall patient health, may encompass antibiotic and prokinetic treatments, probiotic supplementation, and, in select instances, intravenous immunoglobulin (IVIG) administration