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[21] Furthermore, an animal study in ewes demonstrated that a B 12 , folate and methionine restricted diet around conception, resulted in offspring with higher adiposity, blood pressure and insulin resistance which could be accounted for by altered DNA methylation patterns

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Cairns BMJ Open 2019 UK incidence climbing 2.55 to 9.33/100,000 person-years

Started with 0.25 mg injected subcutaneously each morning before breakfast