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The role of ACC in regulating malonyl-CoA synthesis in the hypothalamus leading to anorexigenic effects has been demonstrated in studies on leptin

Glucagon-like peptide-1 (GLP-1) receptor agonists, FDA-approved medications for type 2 diabetes and obesity, are increasingly recognized for potential anti-inflammatory properties beyond their metabolic effects

However, insurance approval may be denied if you lack a covered comorbidity, even with a physician's recommendation

Fortunately, clinical trials in MASH have not revealed any such effects to date

Digestive Diseases and Sciences, 66 (5), 1444-1454

The pharmacological options were embarrassing: a few stimulants with edges sharp enough that most physicians refused to prescribe them, a couple of lipase inhibitors with a side-effect profile so gruesome it functioned as accidental aversion therapy, and a small number of older drugs that had to be repurposed off-label