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Impaired mitochondrial function in brain cells reduces plasticity, impairing synaptic functioning and decreasing cellular resilience.[ref] Is elevated cortisol the only way to cause mitochondrial dysfunction

Because it wasnt that much

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Some antidepressants with known anti-inflammatory effects have been shown to reduce the level of IL-6 and IL-1 in patients with MDD (88, 90)

Science 319 , 13521355 (2008)