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the gastric inhibitory polypeptide and parathyroid hormone 1 receptors) ( 20 )

Education and training : Patients should receive structured education (such as DESMOND or equivalent programmes) covering medication administration, self-monitoring techniques, interpretation of results, and when to seek help

Additionally, hormonal changes occur during weight loss, including alterations in leptin, ghrelin, and other appetite-regulating hormones, which may increase hunger signals and reduce satiety over time

However, if split dosing improves your adherence and reduces side effects, the practical benefit may outweigh theoretical pharmacokinetic concerns

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